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ORIGINAL RESEARCH Table of Contents   
Year : 2013  |  Volume : 24  |  Issue : 2  |  Page : 168-171
Immunohistochemical analysis of CK 18 in dental follicles of impacted third molars: A pilot study

1 Department of Oral Pathology, Coorg Institute of Dental Sciences, Virajpet, India
2 Department of Oral and Maxillofacial Surgery, A. B. Shetty Memorial Institute of Dental Sciences, Dheralakatte, Mangalore, India
3 Department of Pathology, Kidwai Memorial Institute of Oncology, M. H. Marigowda Road, Bangalore, India

Correspondence Address:
Anand S Tegginamani
Department of Oral Pathology, Coorg Institute of Dental Sciences, Virajpet
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-9290.116671

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Objective: Odontogenic tumors are lesions derived from epithelial, ectomesenchymal, and/or mesenchymal elements that still are, or have been, part of the tooth-forming apparatus. Approximately 80% of odontogenic tumors occur in the mandible, with a marked predilection for the posterior region, and are often associated with an unerupted tooth. The aim of this study was to determine whether cytokeratin (CK) 18 immunostaining decorated the follicular tissue removed at the time of prophylactic extraction of impacted mandibular third molars, which might suggest oncofetal transformation. Materials and Methods : Fifty-four impactions met the study inclusion criteria, of which 24 cases showed the presence of reduced enamel epithelium and/or connective tissue with odontogenic epithelium, which were subjected to CK 18 immunostaining. Results: All 24 cases with adequate epithelium were CK 18 immunonegative. Conclusion: There was no oncofetal transformation in the odontogenic epithelia of the dental follicles studied. Thus, although we reaffirm that evaluation of follicular tissue is imperative since disease conditions may be found in minute follicular spaces, development of odontogenic cysts and tumors is unlikely.

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