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| CASE REPORT |
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| Year : 2013 |
Volume
: 24 | Issue : 6 | Page
: 753-755 |
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Central odontogenic fibroma: Report of case with immunohistochemical study
Savas Iordanidis1, Athanasios Poulopoulos2, Apostolos Epivatianos2, Lambros Zouloumis1
1 Department of Oral and Maxillofacial Surgery, Dental School, University of Thessaloniki, Thessaloniki, Greece
2 Department of Oral Medicine and Oral Pathology, Dental School, University of Thessaloniki, Thessaloniki, Greece
Correspondence Address:
Athanasios Poulopoulos
Department of Oral Medicine and Oral Pathology, Dental School, University of Thessaloniki, Thessaloniki
Greece
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0970-9290.127627
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Objectives: To report a case of central odontogenic fibroma (COF) with immunohistochemical study.
Clinical Presentation: We describe a case of epithelium-rich type of COF in the posterior region of the mandible of a 39-year-old woman. Immunohistochemical examination showed the odontogenic epithelium to be positive for high-molecular-weight cytokeratins, vimentin and CD99, and negative for CAM5.2. The stroma contained some myofibroblasts and many fibroblast-like cells positive for CD99.
Conclusion: Our immunohistochemical findings, and especially the positive expression of vimentin from the epithelial cells of COF suggests that these cells are primordial. Last but not least, the presence of a relative small number of myofibroblasts in the stroma justifies the non-aggressive behavior of the neoplasm and supports that a part of stromal collagen of COF is produced by these cells. |
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