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| ORIGINAL RESEARCH |
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| Year : 2018 |
Volume
: 29 | Issue : 3 | Page
: 280-285 |
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Effect of nonsurgical periodontal therapy on interleukin-34 levels in periodontal health and disease
CN Guruprasad, AR Pradeep
Department of Periodontology, Government Dental College and Research Institute, Bengaluru, Karnataka, India
Correspondence Address:
Dr. C N Guruprasad
Department of Periodontology, Government Dental College and Research Institute, Bengaluru - 560 002, Karnataka
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ijdr.IJDR_527_17
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Background: Interleukin-34 (IL-34) is a recently identified alternative ligand for colony-stimulating factor-1 receptor plays an important role in osteoclastogenesis. The aim of this study was to evaluate the IL-34 levels in gingival crevicular fluid (GCF) and plasma in subjects with chronic periodontitis and to evaluate the effect of nonsurgical periodontal therapy on the GCF and plasma IL-34 levels. Materials and Methods: Thirty individuals (age range: 30–56 years) were selected and divided into groups based on the gingival index, probing pocket depth, clinical attachment level, and radiologic parameters (bone loss): Group I (15 individuals with healthy periodontium), Group II (15 individuals with chronic generalized periodontitis) while Group II patients after 8 weeks of the treatment (scaling and root planning) constituted Group III. GCF samples and plasma samples were collected to estimate the levels of IL-34 using enzyme-linked immunosorbent assay kit. Results: The mean IL-34 concentration in GCF and plasma was highest for Group II compared to Group I and decreased after nonsurgical periodontal therapy in chronic generalized periodontitis group. The difference between them was statistically significant (P < 0.05). Conclusion: IL-34 can be considered as an “inflammatory marker” of periodontal disease and can be explored in the future as a potential therapeutic target in the treatment of periodontal disease. |
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