Indian Journal of Dental Research

: 2013  |  Volume : 24  |  Issue : 3  |  Page : 393-

Nanobacteria in dental pulp stones

Neeta Sharma 
 Department of Oral Medicine and Radiology, Mahatama Gandhi Dental College, Sitapura, Jaipur, Rajasthan, India

Correspondence Address:
Neeta Sharma
Department of Oral Medicine and Radiology, Mahatama Gandhi Dental College, Sitapura, Jaipur, Rajasthan

How to cite this article:
Sharma N. Nanobacteria in dental pulp stones.Indian J Dent Res 2013;24:393-393

How to cite this URL:
Sharma N. Nanobacteria in dental pulp stones. Indian J Dent Res [serial online] 2013 [cited 2023 Jun 10 ];24:393-393
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I am writing in the response to the article "A radiographic correlation between systemic disorders and pulp stones", IJDR, 21(3), 2010. I would like to add that there are many theories of pulpal calcification. There is also evidence that hypertension, hypercalciuria, gout, and renal lithiasis are predisposing factors to pulpal calcification. [1],[2] Nanobacteria is also found in the calcific plaque of CVD and also in pulpal calcification. [3] Nanobacterium, a submicroscopic blood particle was discovered in 1988 by Finnish researcher Dr. Olavi Kazander at Scripps Research Institute in California. [4] The identification of nanobacteria has been inferred exclusively from the presence of coccoid-shaped particles with diameter of 0.1 μm, in scanning electron micrograph of rock and mineral surfaces. Similar structures have been reported from serum and blood of CVD patients. [3],[4],[5] They are believed to cause pathological extraskeletal calcification. Nanobacteria may act as crystallization nidi for the formation of biogenic apatite structures in tissue calcification found in, e.g., atherosclerotic plaques, extensive metastatic and tumoral calcification, acute periarthritis, and malignant disease. In nanobacteria-infected fibroblasts, electron microscopy revealed intra- and extracellular needle-like crystal deposits, which were stainable with von Kossa stain and resemble calcospherules found in pathological calcifications. [6] Some investigators indicated the presence of nanobacterial antigens in dental pulp stone and the role of nanobacteria in dental pulp stone formation was shown by nanobacterial colonization and mineralization in human tooth in vitro. [5]


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