Indian Journal of Dental Research

ORIGINAL ARTICLE
Year
: 2022  |  Volume : 33  |  Issue : 1  |  Page : 90--93

Evaluation of antimicrobial activity of chlorhexidine-containing oral gels against aspiration pneumonia-inducing bacteria: An In Vitro study


Sun-Young Han1, Jiyeon Roh2, Yun-Sook Jung3, Ki-Rim Kim3 
1 Department of Dental Hygiene, College of Software and Digital Healthcare Convergence, Yonsei University, Wonju, Korea
2 Forensic Science Training and R&D Center, National Forensic Service, Wonju, Korea
3 Department of Dental Hygiene, Kyungpook National University, Sangju, Korea

Correspondence Address:
Prof. Ki-Rim Kim
Department of Dental Hygiene, Kyungpook National University, 2559, Gyeongsang-daero, Sangju, 37224
Korea

Aim: Hospitalised patients have a high risk of developing aspiration pneumonia because of poor oral care and oral microbial flora changes. Chlorhexidine (CHX) solution has been used to reduce inflammation and prevent infections in oral cavity, but it is difficult to use in inpatients. Gel-type antimicrobial agents rather than the liquid form may be effective for the oral management of hospitalised patients. Therefore, we evaluated the in vitro antimicrobial effects of CHX-containing oral gels on aspiration pneumonia-inducing bacteria compared to the CHX solution. Materials and Methods: The experimental products of two oral gel types containing 1% and 0.1% CHX, respectively, were selected. Hexamedine, a 0.12% CHX solution, was used as a positive control. The antimicrobial activity of CHX agents against six pneumonia-causing bacteria and Streptococcus mutans, one of the most common oral bacteria, was comparatively analysed using the agar disk diffusion method. Results: In the disk diffusion assay, the 1% CHX gels showed the highest inhibitory effect on all bacteria. All CHX agents including gels and solution had the highest antibacterial activity against Staphylococcus aureus compared with other bacteria. Conclusions: We confirmed the significant antimicrobial effects of the 1% CHX oral gels on aspiration pneumonia-inducing bacteria. These results suggest that CHX gels may be an effective oral care method for preventing infection in inpatients who have difficulty using the solution.


How to cite this article:
Han SY, Roh J, Jung YS, Kim KR. Evaluation of antimicrobial activity of chlorhexidine-containing oral gels against aspiration pneumonia-inducing bacteria: An In Vitro study.Indian J Dent Res 2022;33:90-93


How to cite this URL:
Han SY, Roh J, Jung YS, Kim KR. Evaluation of antimicrobial activity of chlorhexidine-containing oral gels against aspiration pneumonia-inducing bacteria: An In Vitro study. Indian J Dent Res [serial online] 2022 [cited 2022 Dec 6 ];33:90-93
Available from: https://www.ijdr.in/article.asp?issn=0970-9290;year=2022;volume=33;issue=1;spage=90;epage=93;aulast=Han;type=0